Drug Chart for Chemotherapy

Drug for Chemotherapy
Generic Name Brand Name Use Method of Action Schedule Adverse Effects
Carboplatin Paraplatin metastatic disease Inhibits DNA synthesis IV every three weeks Decreased immunity, bruising or bleeding, nausea or vomiting, loss of appetite, tiredness and weakness
Capecitabine Xeloda For metastatic disease resistant to anthracyclines and Taxol Converted to 5-FU in body.Prevents DNA and RNA synthesis Oral twice a day over 3 week cycles — 2 weeks on Xeloda, 1 week off Nausea, diarrhea, tingling hands and feet, fatigue, anemia, reduced immunity
Cyclophosphamide Cytoxan Primary therapy and metastatic disease Interferes with tumor cell growth IV every three weeks; oral in 3-week cycles — 2 weeks on Taxotere, 1 weekoff Temporary or permanent infertility, hair loss, cystitis, immune suppression
Docetaxel Taxotere Locally advanced or metastatic disease after failure of first treatment Inhibits cell division IV High dose every 3 weeks; low dose weekly Fluid retention, suppressed immunity, hair loss, loss of feeling in hands,feet
Doxorubicin Adriamycin, Rubex Primary therapy and metastatic disease Inhibits DNA synthesis IV every 21 days Nausea, hair loss, immune suppression; may cause heart damage,increased risk of leukemia
Epirubicin Ellence Primary therapy and metastatic disease Inhibits DNA synthesis IV every 21 days Nausea, hair loss, immune suppression; may be less toxicto heart than doxorubicin, increased risk of leukemia
Etoposide VePesid Metastatic disease Stops cell division Oral twice a day over 3 week cycles — 2 weeks on VePesid,1 week off Immune suppression, nausea, diarrhea
5-Fluorouracil (5-FU) Primary and metastatic disease Prevents DNA and RNA synthesis IV days 1and 8 every 21 days; with leucovorin days 1 through3 every 28 days Nausea, diarrhea,tingling hands and feet, fatigue, anemia,reduced immunity,less hairloss than other drugs
Gemicitabine Gemzar Metastatic Disease–
first-line treatment
in combination with
paclitaxel in women
who already had an anthracycline, unless anthracyclines were contraindicated
Stops cells from making and repairing DNA Fatigue, skin rash, reduced immunity, shortness of breath, diarrhea, bruising more easily
Ixabepilone Ixempra Metastatic Disease–
or locally advanced
disease resistant to
an anthracycline (such as doxorubicin or epirubicin),
a taxane (such as paclitaxel or docetaxel),
capecitabine (Xeloda). Or with capecitabine after treatment wiuh an anthracycline and a taxane.
A microtubule inhibitor, and a member of a new class of drugs called epothilones. Stops cancer cell by disrupting the formation of the microtubules, which are part of the cell’s skeleton. IV every three weeks Neuropathy, fatigue,
hair loss, nausea, vomiting, diarrhea, and musculoskeletal pain. Cannot be used by women with liver problems.
Lapatinib Tykerb Used in combination with capecitabine (Xeloda) for women with advanced or metastatic HER2-positive tumors who have already used Herceptin, an anthracycline, and a taxane Binds to the EGFR and HER2 receptors to inhibit tumor cell growth 1,250 mg (5 tablets) given orally once daily on Days 1-21 Diarrhea, vomiting, nausea, fatigue, unpleasant or painful feeling in the palms of the handq and the soles of the feet, and rash
Methotrexate Primary and metastatic disease Interferes with DNA synthesis and repair V days 1 and 8 every 21 days Immune suppression, nausea, gastrointestinal distress, flu-likesymptoms
Mitoxantrone Novantrone Metastatic disease. May be less effective than doxorubicinand epirubicin Inhibits DNA synthesis IV every 21 days Nausea, hair loss, immune suppression; may cause heart damage,increased risk of leukemia
Mitomycin C Mutamycin Metastatic disease Inhibits DNA synthesis IV once every 6 weeks Nausea, hair loss, immune suppression; may cause heart damage,increased risk of leukemia
Paclitaxel protein-bound particles Abraxane Metastatic disease or relapse within 6 months of adjuvant chemotherapy. Prior therapy should have included an anthracyline, unless clinically contraindicated Active agent is paclitaxel, which inhibits cells divison, but uses a human protein instead of a solvent,!which allows the drug to be administered in only 30 minutes IV; doctor will determine dose and schedule Decreased immunity, tingling in the hands and feet
Paclitaxel Taxol Metastatic disease, can also be used in the adjuvant setting.For more info, click here Inhibits cell division IV High dose every 3 weeks; low dose!weekly Fluid retention, suppressed immunity, hair loss, loss offeeling in hands, feet
Trastuzumab Herceptin For primary and metastatic disease in women with HER2-positive tumors Blocks HER2, a growth factor receptor, to inhibit tumorcell growth IV weekly Anemia, immune suppression, flulike symptoms

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