Genetic variants associated with breast cancer risk for Ashkenazi Jewish women with strong family histories but no identifiable BRCA1/2 mutation.

Read this article on the Human Genetics website.

Publication Details
Rinella ES, Shao Y, Yackowski L, Pramanik S, Oratz R, Schnabel F, Guha S, LeDuc C, Campbell CL, Klugman SD, Terry MB, Senie RT, Andrulis IL, Daly M, John EM, Roses D, Chung WK, Ostrer H. Human Genetics, May 2013

Study Information
Jewish Women’s Breast and Ovarian Cancer Genetic Study

This study at New York University School of Medicine and Albert Einstein College of Medicine, in New York City, is studying DNA from Ashkenazi Jewish women for two reasons: to try to identify new genes that might reduce breast and ovarian cancer risk in women who have a BRCA1 and BRCA2 mutation; and to try to identify genes, other than BRCA 1 and BRCA2, that increase breast and ovarian cancer risk in Ashkenazi Jewish women. The researchers initially wanted to enroll at least 1,000 women of Ashkenazi Jewish descent; they later increased their enrollment goal to a minimum of 2,000 women after the tremendous response from Army of Women members. The Call to Action for this study was sent to Army of Women members on November 10, 2010. When the researchers closed enrollment on June 9, 2011, the Army of Women had provided them with 4,620 women who were interested in enrolling in the study.

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