Steven Narod, MD, Women’s College Research Institute, Toronto, Ontario, Canada


Genetic and non-genetic factors are believed to influence whether a woman with a BRCA1, BRCA2, and/or PALB2 mutation goes on to develop breast and/or ovarian cancer. The study is trying to identify which hormonal, reproductive, and lifestyle factors may increase cancer risk in this high-risk group.

What does participation involve?
If you agree to participate in the Risk Factor Analysis of Hereditary Breast and Ovarian Cancer study you will be asked to complete a baseline questionnaire and provide information about your medical history, family history of cancer, and factors related to your lifestyle. You will be asked to authorize members of the research team to access your pathology and medical records for research purposes. The research team will contact you every two years, asking you to complete a questionnaire that will provide them with an update on your health. Each questionnaire will take you about 30 minutes to complete. You may choose to end your participation in the study at any time.

Participants will be asked to contribute to this study for a maximum of 20 years. The questionnaire data may be sent to other academic institutions for additional studies on genetic cancers. The data shared with other institutions will not include any identifiable data, keeping your responses anonymous. Data from the questionnaire will not be used for purposes other than the study of familial cancer.

Anywhere in the world

How can I sign up for this study?

You can sign up for this study if you match all of these main criteria. Please read this list carefully.

  • You are a woman over the age of 18
  • You are a woman with or without a personal history of breast cancer, and have been determined to be a genetic carrier of a BRCA1, BRCA2, and/or PALB2 mutation by molecular analysis
  • You are able to read and write in English

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